2004-2011，中山大学，本硕。
2012-2015,北京协和医学院&清华大学医学部 医学博士学位。
2016-2018，中国中医科学院中药研究所，博士后。
2019-2020，美国stowers institute for medical research 研究所，博士后。
2021-2022，中国农业科学院生物技术研究所,助理研究员。
2023-至今，中国农业科学院生物技术研究所,副研究员。

玉米高产耐逆协同改良基因资源挖掘和智能设计技术研究，获得中国农业科学院科学技术成果奖杰出科技创新奖等奖励，主持农业生物育种重大专项子课题、北京市自然基金、中国农业科学院课题等；在Nature Communications、Cell Reports、Molecular Plant、Plant Communications、Plant Biotechnology Journal、New Phytologist 等国际期刊发表SCI论文30多篇,H指数20，高被引论文3篇；担任Agriculture Communications学术编辑及青年编委等。担任Advanced Science, Phytomedicine, Genes & diseases等10多个期刊审稿人。

研究领域：

聚焦玉米高产耐逆协同调控遗传基础和设计改良，通过生物信息学及人工智能技术，结合基因编辑以及合成生物学等技术手段，解析作物株型、产量、环境适应性等重要农艺性状的遗传调控网络和分子机制，借助人工智能技术进行玉米重要农艺性状的智能设计和遗传改良，为高产优质的智能适应作物新品种提供理论支持和新材料。

发表论文：

1.Ting Wang, Fanhua Wang, Shuhan Deng, Kailai Wang, Dan Feng, Fan Xu, Weijun Guo, Jia Yu, Yue Wu, Hada Wuriyanghan, Shang-Tong Li, Xiaofeng Gu, Liang Le*, Li Pu*. Single-cell transcriptomes reveal spatiotemporal heat stress response in maize roots. Nat Communications, 2025, 16, 177.排名：通讯作者，IF=15.7,中科院1区

2.Weijun Guo,Fanhua Wang,Jianyue Lv,Jia Yu,Yue Wu,Hada Wuriyanghan,Liang Le*,Li Pu*.Phenotyping, genome‐wide dissection, and prediction of maize root architecture for temperate adaptability. iMeta, 2025,4(2):e70015. 排名：通讯作者，IF=33.2,中科院1区

3.Weixiang Wang#, Senlin Xiao#, Fan Que#, Liang Le#, Aiguo Su, Zhihuan Zhou,Xiangzhang Zhu,Yanbing Zhang,Liyu Shi,Tao Zhong,Haixia Zhang,Jinfeng Xing,Min Lu,Ruyang Zhang,Ronghuan Wang, Wei Song,Jiuran Zhao.Maize Knows Friends or Foes? The Dark Side of Trichoderma asperellum as a Maize Ear Rot Pathogenic Fungus.Plant Biotechnology Journal,2026. 排名：共同第一 

4.Baoping Jiang*, Jiayi Si, Hongmei Luo, Liang Le*.Single-cell omics reveal the mechanisms of traditional Chinese medicines. Phytomedicine, 2025,147,157204. 排名：最后通讯 

5.Weijun Guo#,Liang Le#, Daolei Zhang#,Ziwei Wei#,Yifan Wang, Yue Wu, Hada Wuriyanghan, Xiaofeng Gu, Li Pu. Heat stress responses mediated by N6-methyladenine DNA methylation in maize. Cell Reports, 2025,116058. 排名：共同第一 

6.Daolei Zhang, Fan Xu, Fanhua Wang, Liang Le*, Li Pu*.Synthetic biology and artificial intelligence in crop improvement. Plant Communications, 2025, 6(2)：101220, 排名：通讯作者. Q1区,IF=11.6,中科院1区

7.Daolei Zhang, Yujun Gan, Liang Le*,Li Pu*. Epigenetic variation in maize agronomical traits for breeding and trait improvement. Journal of Genetics and Genomics,2025,52(3):307-318.排名：通讯作者. IF=7.1

8.Fan Xu, Daolei Zhang, Liang Le*, Li Pu*. Polycomb and trithorax: Their yin-yang dynamics in plants. Molecular Plant, 2024, 17(6): 845-847  排名：通讯作者.IF=24

9.Liang Le#, Weijun Guo#, Danyao Du#, Xiaoyuan Zhang#, Weixuan Wang, Jia Yu, Huan Wang, Hong Qiao, Chunyi Zhang*, Li Pu*. A spatiotemporal transcriptomic network dynamically modulates stalk development in maize. Plant Biotechnology Journal. 2022, 20, 2313–2331.  IF=13.3, 排名：第一作者

10.Jia Yu#, Guangshu Song#, Weijun Guo#, Liang Le#, Fan Xu, Ting Wang, Fanhua Wang, Yue Wu, Xiaofeng Gu, Li Pu. ZmBELL10 interacts with other ZmBELLs and recognizes specific motifs for transcriptional activation to modulate internode patterning in maize. New Phytologist, 2023, 240(2):577-596.   IF=9.4, 排名：共同第一作者

11.Weixuan Wang#, Weijun Guo#, Liang Le#, Jia Yu#, Yue Wu, Dongwei Li, Yifan Wang, Huan Wang, Xiaoduo Lu, Hong Qiao, Xiaofeng Gu, Jian Tian, Chunyi Zhang, Li Pu. Integration of high-throughput phenotyping, GWAS, and predictive models reveals the genetic architecture of plant height in maize. Molecular Plant, 2023, 16(2):354-373. IF=21.9, 排名：第一作者

12.Ji Pang, Liang Le#, Yi Zhou#, Renjun Tu, Qiang Hou, Dai Tsuchiya, Nancy Thomas, Yongfu Wang, Zulin Yu, Richard Alexander, Marina Thexton, Brandy Lewis, Timothy Corbin, Michael Durnin, Hua Li, Ruth Ashery-Padan, Deyue Yan, and Ting Xie*. NOTCH Signaling Controls Ciliary Body Morphogenesis and Secretion by Directly Regulating Nectin Protein Expression. Cell Reports, 2021, 34 (108603). 

13.Liang Le, Hui Fu, Qiuyue Lv, Xue Bai, Ying Zhao, Jiamei Xiang, Baoping Jiang*, Keping Hu, Shilin Chen*, ″The protective effects of the native favanone favanomarein on neuronal cells damaged by 6-OHDA″, Phytomedicine, 2019,53, 193-204. IF=4.26, 排名：第一作者