林 浩博士、研究员、博士生导师

博士
研究员
博士生导师
作物功能基因组研究中心主任

linhao@caas.cn
研究中心

作物功能基因组

创新团队

作物高光效功能基因组

课 题 组

林浩课题组

招生方向

生物化学与分子生物学

学习工作经历

2002年7月 东北师范大学获学士学位;
2009年7月 中国科学院遗传与发育生物学研究所获博士学位;
2010年2月至2013年8月 美国俄克拉荷马州立大学从事博士后研究;
2013年9月至今 中国农业科学院生物技术研究所研究员、博士生导师。

主要研究领域与成果

主要研究领域与成果:

瞄准国家新时期农业供给侧结构性改革和种业科技创新重大需求,开展苜蓿等饲草作物功能基因组与遗传改良研究。主持承担国家973计划课题、国家自然科学基金等多项国家级课题。迄今已在Plant Cell、PNAS、PLoS Genet等国内外学术期刊上发表论文30余篇,申请国家发明专利12项、获授权8项,参与育成国审牧草新品种1个。担任《Frontiers in Genome Editing》、《草学》等期刊编委。


主要论著:

32. Lin H, Meng Y, Tadege M, Niu L*. Function of Medicago WOX genes and their diversity. THE MEDICAGO TRUNCATULA GENOME (In press), 978-3-030-90756-3.

31. Wang N, Xia X, Jiang T, Li L, Zhang P, Niu L, Cheng H, Wang K, Lin H*. In planta haploid induction by genome editing of DMP in the model legume Medicago truncatula. Plant Biotechnol J 2022, 20:22-24.

30. Li W#, Ma Q#, Yin P#, Wen J, Pei Y, Niu L*, Lin H*. The GA 20-Oxidase Encoding Gene MSD1 Controls the Main Stem Elongation in Medicago truncatula. Front Plant Sci 2021, 12:709625.

29. Zhang P, Liu H, Mysore KS, Wen J, Meng Y, Lin H, Niu L*. MtFDa is essential for flowering control and inflorescence development in Medicago truncatula. J Plant Physiol 2021, 260:153412.

28. Wang C#, Ji W#, Liu Y, Zhou P, Meng Y, Zhang P, Wen J, Mysore KS, Zhai J, Young ND, Tian Z, Niu L, Lin H*. The antagonistic MYB paralogs RH1 and RH2 govern anthocyanin leaf markings in Medicago truncatula. New Phytol 2021, 229: 3330-3344.

27. Zhang P, Wang R, Wang X, Mysore KS, Wen J, Meng Y, Gu X, Niu L, Lin H*. MtFULc controls inflorescence development by directly repressing MtTFL1 in Medicago truncatula. J Plant Physiol 2021, 256: 153329.

26. Wang C#, Wang H#, Zhu H, Ji W, Hou Y, Meng Y, Wen J, Mysore KS, Li X, Lin H*. Genome-wide identification and characterization of cytokinin oxidase/dehydrogenase family genes in Medicago truncatula. J Plant Physiol 2021, 256: 153308.

25. 孙志康, 王娜, 孟颖颖, 林浩, 牛丽芳*, 蒺藜苜蓿糖基转移酶基因SMALL AND EMERALD1的克隆和功能研究, 生物技术进展 2021, 2: 182-189.

24. Zhu B#, Li H#, Xia X#, Meng Y, Wang N, Li L, Shi J, Pei Y, Lin M, Niu L, Lin H*. ATP binding cassette G transporters SGE1 and MtABCG13 control stigma exsertion. Plant Physiol2020, 184: 223-235.

23. Cao S#*, Luo X#, Xie L#, Gao C, Wang D, Holt BF 3rd, Lin H, Chu C, Xia X. The florigen interactor BdES43 represses flowering in the model temperate grass Brachypodium distachyon. Plant J 2020, 102:262-275.

22. Yin P, Ma Q, Wang H, Feng D, Wang X, Pei Y, Wen J, Tadege M, Niu L* and Lin H*. SMALL LEAF AND BUSHY1 controls organ size and lateral branching by modulating the stability of BIG SEEDS1 in Medicago truncatula. New Phytol 2020, 226: 1399-1412.

21. Meng, Y, Wang, C, Yin, P, Zhu, B, Zhang, P, Niu, L*, Lin H*. “Targeted mutagenesis by an optimized agrobacterium-delivered CRISPR/Cas 9 system in the model legume Medicago truncatula,” in The Model Legume Medicago truncatula, ed. F. D. Bruijn (Hoboken, NJ: Wiley), 2019,1015–1018. doi: 10.1002/9781119409144.ch130

20. Meng Y#, Wang Z#, Wang Y, Wang C, Zhu B, Liu H, Ji W, Wen J, Chu C, Tadege M, Niu L, Lin H*. The MYB Activator WHITE PETAL1 Associates with MtTT8 and MtWD40-1 to Regulate Carotenoid-Derived Flower Pigmentation in Medicago truncatula. Plant Cell 2019, 31:2751-2767.

Ø Featured in Plant Cell by Carella P. Mellowed Yellow: WHITE PETAL1 Regulates


Carotenoid Accumulation in Medicago Petals.
2019 Nov;31(11):2556-2557.


Ø Recommended in F1000Prime as being of special significance in its field by F1000


Faculty Member Chang-Hsien Yang. (https://facultyopinions.com/prime/thefaculty/member/1022555/contact?utm_medium=email&utm_source=prime_ypp)

19. Zhu B#, Li H#, Hou Y#, Zhang P, Xia X, Wang N, Wang H, Mysore KS, Wen J, Pei Y, Niu L*, Lin H*. AGAMOUS AND TERMINAL FLOWER controls floral organ identity and inflorescence development in Medicago truncatula. J Integr Plant Biol 2019, 61: 917-923.

18. 马青霞, 殷鹏程, 林浩, 金竹萍, 王欢庆, 杨江平, 裴雁曦*, 牛丽芳*, 蒺藜苜蓿赤霉素氧化酶基因MtGA20ox的功能解析, 生物技术进展 2019, 9: 161-168.

17. 王瑞良, 张鹏程, 牛丽芳, 朱昊, 李学森, 王兴春*, 林浩*, 蒺藜苜蓿MtFVE基因功能初步解析, 生物技术进展 2019, 9: 152-160.

16. Chen S*, Wu F, Li Y, Qian Y, Pan X, Li F, Wang Y, Wu Z, Fu C, Lin H, Yang A*. NtMYB4 and NtCHS1 are critical factors in the regulation of flavonoid iosynthesis and are involved in salinity responsiveness. Front Plant Sci 2019,10: 178.

15. Meng Y#, Liu H#, Wang H#, Liu Y, Zhu B, Wang Z, Hou Y, Zhang P, Wen J, Yang H, Mysore KS, Chen J, Tadege M, Niu L*, Lin H*. HEADLESS, a WUSCHEL homolog, uncovers novel aspects of shoot meristem regulation and leaf blade development in Medicago truncatula. J Exp Bot 2019, 70: 149-163.

14. Wang M#, Li W#, Fang C#, Xu F#, Liu Y#, Wang Z, Yang R, Zhang M, Liu S, Lu S, Lin T, Tang J, Wang Y, Wang H, Lin H, Zhu B, Chen M, Kong F, Liu B, Zeng D, Jackson S*, Chu C*, and Tian Z*. Parallel domestication selection of a dormancy gene in crops from multiple families. Nat Genet 2018, 50: 1435-1441.

13. Zhu B#, Li H#, Wen J, Mysore KS, Wang X, Pei Y, Niu L*, Lin H*. Functional specialization of duplicated AGAMOUS homologs in regulating floral organ development of Medicago truncatula. Front Plant Sci 2018, 9:854.

12. 李辉, 殷鹏程, 祝步拓, 林浩, 刘志强, 裴雁曦*, 牛丽芳*, 蒺藜苜蓿株高控制基因COSTIN的克隆及功能研究, 生物技术进展 2018, 8: 124-131.

11. 刘欢, 孟颖颖, 牛丽芳, 林浩*, 基因编辑技术研究进展及其在苜蓿等豆科饲草作物中的应用, 生物工程学报 2017, 33: 1733-1743.

10. Wang H#, Niu L#, Fu C#, Meng Y, Sang D, Yin P, Wu J, Tang Y, Lu T, Wang ZY, Tadege M*, Lin H*. Overexpression of the WOX gene STENOFOLIA improves biomass yield and sugar release in transgenic grasses and display altered cytokinin homeostasis. PLoS Genet 2017, 13: e1006649.

9. Meng Y, Hou Y, Wang H, Ji R, Liu B, Wen J, Niu L*, Lin H*. Targeted mutagenesis by CRISPR/Cas9 system in the model legume Medicago truncatula. Plant Cell Rep 2017, 36: 371-374.

8. Niu L#, Fu C#, Lin H# , Wolabu TW, Wu Y, Wang ZY, Million T*. Control of floral transition in the bioenergy crop switchgrass. Plant Cell Environ 2016, 39: 2158-2171.

7. Wu Z, Cao Y, Yang R, Qi T, Hang Y, Lin H, Zhou G, Wang ZY, Fu C*. Switchgrass SBP-box transcription factors PvSPL1 and 2 function redundantly to initiate side tillers and affect biomass yield of energy crop. Biotechnol Biofuels 2016, 9:101.

6. Niu L#, Lin H#, Zhang F, Wolabu TW, Li G, Tang Y, Wen J, Ratet P, Mysore KS, Tadege M*. LOOSE FLOWER, a WUSCHEL-like Homeobox gene, is required for lateral fusion of floral organs in Medicago truncatula. Plant J 2015, 81:480-492.

5. Lin H#, Niu L#, McHale NA, Ohme-Takagi M, Mysore KS, Tadege M*. Evolutionarily conserved repressive activity of WOX proteins mediates leaf blade outgrowth and floral organ development in plants. Proc Natl Acad Sci USA 2013, 110: 366-371.

4. Lin H, Niu L, Tadege M*. STENOFOLIA acts as a repressor in regulating leaf blade outgrowth. Plant Signal Behav 2013, 8, e24464.

3. Tadege M*, Lin H, Bedair M, Berbel A, Wen J, Rojas CM, Niu L, Tang Y, Sumner L, Ratet P, McHale NA, Madueño F, Mysore KS. STENOFOLIA regulates blade outgrowth and leaf vascular patterning in Medicago truncatula and Nicotiana sylvestris. Plant Cell 2011, 23: 2125-2142.

2. Tadege M*, Lin H, Niu L, Mysore KS. Control of dicot leaf blade expansion by a WOX gene, STF. Plant Signal Behav 2011, 6: 1861-1864.

1. Lin H#, Wang R#, Qian Q#, Yan M, Meng X, Fu Z, Yan C, Jiang B, Su Z, Li J, Wang Y*. DWARF27, an iron-containing protein required for the biosynthesis of strigolactones, regulates rice tiller bud outgrowth. Plant Cell 2009, 21: 1512-1525.