Liang Z

博士
研究员
博士生导师

liangzhe@caas.cn
研究中心

作物分子生物学研究中心

创新团队

作物耐逆性调控与改良创新团队

课 题 组

Liang Zhe课题组

招生方向

生物化学与分子生物学

学习工作经历

2012年11月,挪威生命科学大学获博士学位
2014年2月-2019年2月,新加坡国立大学,Research Fellow
2019年3月-2021年3月,德国海德堡大学,Research Fellow
2021年4月-今,中国农业科学院生物技术研究所,研究员
2021年7月入选中国农科院农科英才“领军人才”B类

主要研究领域与成果

主要利用多维组学、生物化学、分子生物学、群体遗传学和单细胞技术,研究RNA甲基化对植物抗逆及对作物重要农艺性状调控机理。主要包括:1,RNA甲基化在植物抗逆中的作用;2,RNA甲基化对作物重要农艺性状的调控机理;3,单细胞水平解析植物发育和抗逆的机理;4,单细胞水平作物功能基因的挖掘及调控性状的机理。

发表文章:

1.Zhao K, Li Z, Ke Y, Ren R, Cao Z, Li Z, Wang K, Wang X, Wang J, Ma Q, Cao D, Zhao K, Li Y, Hu S, Qiu D, Gong F, Ma X, Zhang X, Fan G, Liang Z, Yin D. Dynamic N6-methyladenosine RNA modification regulates peanut resistance to bacterial wilt. New Phytologist 2024, doi: 10.1111/nph.19568.

2.Zeng J, Zhao X, Liang Z, Hidalgo I, Gebert M, Fan P, Wenzl C, Gornik S, Lohmann J. Nitric oxide controls shoot meristem activity via regulation of DNA methylation. Nature Communications 2023, doi: 10.1038/s41467-023-43705-1

3.Cui J, Zhu Y, Du H, Liu Z, Shen S, Wang T, Cui W, Zhang R, Jiang S, Wu Y, Gu X, Yu H, Liang Z. Chromosome-level reference genome of tetraploid Isoetes sinensis provides insights into evolution and adaption of lycophytes. GigaScience 2023, giad079.

4.Sun Z, Jiang S, Wang D, Li L, Liu B, Ran Q, Hu L, Xiong J, Tang Y, Gu X, Wu Y, Liang Z. Single-cell RNA-seq of Lotus japonicus provide insights into identification and function of root cell types of legume. Journal of Integrative Plant Biology 2023, 65(5):1147-1152.

5.Feng D*, Liang Z*, Wang Y, Yao J, Yuan Z, Hu G, Qu R, Xie S, Li D, Yang L, Zhao X, Ma Y, Lohmann J, Gu X. Chromatin accessibility illuminates single-cell regulatory dynamics of rice root tips. BMC Biology 2022, 20:274.

6.Xu T, Wu X, Wong CE, Fan S, Zhang Y, Zhang S, Liang Z, Yu H, Shen L. FIONA1-mediated m6A modification regulates the floral transition in Arabidopsis. Advanced Science 2022 e2103628.

7.Hu W*, Ji C*, Liang Z*, Ding Z*, Ye J*, Ou W*, Zhou G, Tie W, Yan Y, Yang J, Yang X, Wei Y, Jin Z, Xie J, Peng M, Wang W, Guo A, Xu B, Guo J, Chen S, Ma L, Wang M, Zhou Y, Li X, Li R, Xiao X, Wan Z, An F, Zhang J, Leng Q, Li Y, Shi, H, Ming R, Li K. Resequencing of 388 cassava accessions identifies valuable loci and selection for variation in heterozygosity. Genome Biology 2021, 12 (1), 1-22.

8.Liang Z*, Zhang Q*, Ji C, Hu G, Zhang P, Wang Y, Yang L, Gu X. Reorganization of the 3D chromatin architecture of rice genomes during heat stress. 2021, BMC Biology 19 (1), 1-10.

9.Hu W*, Ji C*, Shi H*, Liang Z*, Ding Z*, Ye J*, Ou W*, Zhou G, Tie W, Yan Y, Yang J, Yang X, Wei Y, Jin Z, Xie J, Peng M, Wang W, Guo A, Xu B, Guo J, Chen S, Ma L, Wang M, Zhou Y, Li X, Li R, Guo S, Xiao X, Wan Z, An F, Zhang J, Leng Q, Li Y, Ming R, Li K. Allele-defined genome reveals biallelic differentiation during cassava evolution. Molecular Plant 2021, 14: 851-854.

10.Liu Q*, Liang Z*, Feng D*, Jiang S*, Wang Y, Du Z, Li R, Hu G, Zhang P, Ma Y, Lohmann J, Gu X. Transcriptional landscape of rice roots at the single-cell resolution. Molecular Plant 2021, 3:384-394.

11.Yin D, Ji C, Song Q, Zhang W, Zhang X, Zhao K, Chen C, Wang C, He G, Liang Z, Ma X, Li Z, Tang Y, Wang Y, Li K, Ning L, Zhang H, Zhao K, Li X, Yu H, Lei Y, Wang M, Ma L, Zheng H, Zhang Y, Zhang J, Hu W, Chen ZJ. Comparison of Arachis monticola with diploid and cultivated tetraploid genomes reveals asymmetric subgenome evolution and improvement of peanut. Advanced Science 2020, doi: advs.201901672.

12.Li C, Gong X, Zhang B, Liang Z, Wong CE, See BYH, Yu H. TOP1alpha, UPF1, and TTG2 regulate seed size in a parental dosage-dependent manner. PLoS Biology 2020, 18:e3000930.

13.Liang Z*, Geng Y*, Ji C*, Du H*, Wong C, Zhang Q, Zhang Y, Zhang P, Riaz A, Chachar S, Ding Y, Wen J, Wu Y, Wang M, Zheng H, Wu Y, Demko V, Shen L, Han X, Zhang P, Gu X, Yu H. Mesostigma viride genome and transcriptome provide insights into the origin and evolution of Streptophyta. Advanced Science 2020, Doi: 10.1002/advs.201901850.

14.Liang Z*, Riaz A*, Chachar S, Ding Y, Du H, Gu X. Epigenetic modifications of mRNA and DNA in plants. Molecular Plant 2020, 13: 14-30.

15.Shen L*, Liang Z*, Wong C, Yu H. Messenger RNA modifications in plants. Trends in Plant Science 2019, 24: 328-341.

16.Wu D*, Liang Z*, Yan T, Xu Y, Tang J, Zhou G, Xuan L, Hua S, Wang H, Wang Q, Zhu L, Maodzeka A, Hussain N, Li Z, Li X, Wu L, Zheng H, Zhang G, Shen L, Yu H, Jiang L. Whole-genome resequencing of a world-wide collection of rapeseed accessions reveals genetic basis of their ecotype divergence. Molecular Plant 2019, 12: 30-43.

17.Liu L, Li C, Liang Z, Yu H. Characterization of multiple C2 domain and transmembrane region proteins in Arabidopsis. Plant Physiology 2018, 176:2119-2132.

18.Zhang Q*, Liang Z*, Cui X*, Ji C, Li Y, Zhang P, Liu J, Riaz A, Yao P, Liu M, Wang Y, Lu T, Yu H, Yang D, Zheng H, Gu X. N6-methyladenine DNA methylation in Japonica and Indica rice genomes and its association with gene expression, plant development and stress responses. Molecular Plant 2018, 12:1492-1508.

19.Liang Z*, Yu G*, Liu J*, Geng Y, Mao J, Wang D, Zhou J, Gu X. The N6-adenine methylation in yeast genome profiled by single-molecule technology. Journal of Genetics and Genomics 2018, 45:223-225.

20.Xiao C, Zhu S, He M, Chen, Zhang Q, Chen Y, Yu G, Liu J, Xie S, Luo F, Liang Z, Wang D, Bo X, Gu X, Wang K, Yan G. N6-methyladenine DNA modification in the human genome. Molecular Cell 2018, 71:306-318 e307.

21.Liang Z*, Shen L*, Cui X*, Bao S, Geng Y, Yu G, Liang F, Xie S, Lu T, Gu X, Yu H. DNA N6-Adenine methylation in Arabidopsis thaliana. Developmental Cell 2018, 45:406-416 e403.

22.Liang Z*, Geng Y*, Gu X. Adenine methylation: new epigenetic marker of DNA and mRNA. Molecular Plant 2018, 11:1219-1221.

23.Cui X*, Liang Z*, Shen L*, Zhang Q, Bao S, Geng Y, Zhang B, Leo V, Vardy LA, Lu T, Gu X, Yu H. 5-Methylcytosine RNA methylation in Arabidopsis thaliana. Molecular Plant 2017, 10:1387-1399.

24.Shen L*, Liang Z*, Gu X, Chen Y, Teo ZW, Hou X, Cai WM, Dedon PC, Liu L, Yu H. N6-Methyladenosine RNA modification regulates shoot stem cell fate in Arabidopsis. Developmental Cell 2016, 38:186-200.

25.Liang Z, Brown RC, Fletcher JC, Opsahl-Sorteberg HG. Calpain-mediated positional information directs cell wall orientation to sustain plant stem cell activity, growth and development. Plant and Cell Physiology 2015, 56:1855-1866.

26.Liang Z, Demko V, Wilson RC, Johnson KA, Ahmad R, Perroud PF, Quatrano R, Zhao S, Shalchian-Tabrizi K, Otegui MS, Olsen OA, Johansen W. The catalytic domain CysPc of the DEK1 calpain is functionally conserved in land plants. Plant Journal 2013, 75:742-754.