E-mail：zhangyuhong@caas.cn

Research Area：

Microbial enzyme gene engineering

Publications：

1.Tian, Jian，Woodard, Jaie，Whitney, Anna，Shakhnovich, Eugene* (Corresponding author)，Thermal Stabilization of DihydrofolateReductaseusing Monte Carlo Unfolding Simulations and its Functional Consequences，PLoS Computational Biology, 2015, 11(4):e1004207. 2.Wang, Ping, Huang, Lu, Jiang, Hu, Tian, Jian* (Corresponding author), et al: Improving the Secretion of a Methyl Parathion Hydrolase in Pichia pastoris by Modifying Its N-Terminal Sequence. PLoS One 2014, 9(5):e96974. Tian, Jian, Xu, Li, Zhang, Shuangyu, Sun, Wen, Chu, Xiaoyu, Wu, Ningfeng* (Corresponding author): Draft Genome Sequence of the Organophosphorus-Degrading Bacterium Pseudomonas sp. Strain 1-7, Isolated from Organophosphorus-Polluted Sludge. Genome announcements 2014, 2(5). 4.Tian, Jian, Wang, Ping, Huang, Lu, Chu, Xiaoyu, Wu, Ningfeng* (Corresponding author), Fan, Yunliu: Improving the thermostability of methyl parathion hydrolase from Ochrobactrum sp. M231 using a computationally aided method. ApplMicrobiolBiotechnol 2013, 97:2997–3006. 5.Tian Jian, Zhang Yuhong, Liu Bo, et al: Presep: Predicting the Propensity of a Protein Being Secreted into the Supernatant when Expressed in Pichia pastoris. PLoS One. vol. 8; 2013: e79749. 6.Zhu, Tao#, Tian, Jian#(Equal Contribution), Zhang, Shuangyu, Wu, Ningfeng* (Corresponding author), Fan, Yunliu: Identification of the transcriptional regulator NcrB in the nickel resistance determinant of Leptospirillumferriphilum UBK03. PLoS One 2011, 6(2):e17367. .Tian, Jian, Wu, Ningfeng, Chu, Xiaoyu, Fan, Yunliu: Predicting changes in protein thermostability brought about by single- or multi-site mutations. BMC bioinformatics 2010, 11. 8.Tian, Jian, Wang, Ping, Gao, Shan, Chu, Xiaoyu, Wu, Ningfeng* (Corresponding author), Fan, Yunliu: Enhanced thermostability of methyl parathion hydrolase from Ochrobactrum sp. M231 by rationally engineering a glycine to proline mutation. FEBS Journal 2010, 277:4901-4908.